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The PALL/ATMI PadReactor system is perfectly suited to laboratory environments, process development centers, clinical material supply and flexible GMP manufacturing. The square bioreactor vessel, which offers comparable functionality to classical stirred tank bioreactors, is a single-use bag integrating an internal paddle mixing and sparger system. The sparger is integrated in the paddle mixer to enhance oxygen transfer rates. The innovative bag design improves mixing at low shear forces and allows a non-invasive stirrer connection to the system. The paddle is enclosed in a medical grade ULDPE sleeve, made from the same contact material as the bag itself, and is coupled on top of the vessel with the mechanical mixing head. The PadReactor is available in total volumes of 25L, 50L, 250L, 600L, 1200L and has been used successfully in cultivation of anchorage dependent and suspension cells.

The bioreactor vessel, which offers comparable functionality to classical stirred tank bioreactors, is a single-use bag integrating an internal paddle mixing and sparger system. This innovative bag design allows a non-invasive connection to the system. The paddle is enclosed in a medical grade ULDPE sleeve, made from the same contact material as the bag itself, and is coupled on top of the vessel with the mechanical mixing head.

The Integrity PadReactor utilizes disposable mixing bags made from Integrity TK8 bioprocess film. The product-contacting layer of TK8 film is blow-extruded in-house by Pall under cleanroom conditions using medical-grade ultra low-density polyethylene resin. It is then laminated to create a gas barrier film of exceptional cleanliness, strength, and clarity that is animal derived component free (ADCF) and complies fully with USP Class VI requirements.

The Integrity PadReactor single-use bioreactor consists of the following:
Drive Unit: The flexible drive unit allows the system to cultivate cells in disposable bags. One drive unit can allow the user to mix in multiple disposable mixing bags of various sizes. Each system comes with the appropriate mixing stick for your container.
Mobile Retaining Tank: The purpose of the retaining tank is to support the mixing bag and provide mobility before and after operation. Various tank sizes and options are available.
Bioreactor Vessel: The reactor vessel uses an innovative bag design that allows a non-invasive connection to the mixer. Mixing is achieved when the integrated paddle/sparger inside the bag rotates within the bag.

PAD reactor Volumes

 PAD Type Mini 25 50 125 250 600 1200
 Total Volume (L) 16 25 50 125 250 600 1200
 Working Volume 13 20 40 100 200 480 960
 Minimum Working Volume (L) 3.2 8 10 25 25 120 240

PAD reactor Weight and Dimensions

 Dimension Bag Holder 25L Bag Holder 50L Bag Holder 250L Bag Holder 600L Bag Holder 1200L
 Width 439 mm 439 mm 689 mm 853 mm 1120 mm
 Depth 559 mm 559 mm 878 mm 1075 mm 1265 mm
 Height without Drive Unit 680 mm 700 mm 1425 mm 1435 mm 1600 mm
 Total PadReactor Height 1132 mm 1132 mm 1875 mm 1900 mm 2100 mm
 With Drive Unit Positioned:
 Jacket Liguid Volume 13 L 17 L 44 L 105 L 124 L
 Total Weight (Empty Bag) 74 kg 75 kg 200 kg 225 kg 300 kg

Features

  • Superior mixing capabilities with highly reduced shear stress
  • Innovative sparging device with better oxygenation and kLa
  • Adapted for cultivation of suspended or adherent cells at very high densities
  • Compatible with most Cell culture processes
  • Scalable customizable system
  • No need for CIP/SIP (disposable bag technology)
  • Avoid cross contamination risks
  • Very low working volume

Our Location

Contact

RTD Technology Ltd T/A Asistec
Unit 15A, Solus Tower Estate
Corke Abbey, Bray
Co. Wicklow, A98 X9X7
Tel:  +353  (0)1 281 4650
Tel:  +353  (0)1 281 4064
Fax: +353  (0)1 204 3064


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