Bench Top Bioreactor Systems

Bench Top Bioreactor Systems

General
applikonThe Applikon Bio Bench bioreactor range consists of four different Sterilizable-In-Place bioreactor systems with a total volume of 7 liter, 15 liter, 20 liter and 30 liter. Applications are in basic research and small scale production for both mammalian cells and micro-organisms. The Bio Bench range is a direct scale-up from the lab scale autoclavable bioreactors (the world standard in laboratory research). This eases scale-up and minimizes risks in process transfer to next volume level. The small footprint guarantees that the minimal amount of bench space is occupied by the system. All systems are fully documented for cGMP usage and are supplied with an extensive documentation package to support validation.

Modularity
The standardized design of the systems offers the flexibility needed in R&D to adapt the system to the changing process demands. A wide range of standard modules is available to customize the systems to the specific demands of the customer. The modularity extends to the control tower that can be supplied with the systems. A wide range of add-on packs are available. These standard packs include pressure control, weight control, double gas inlet lines, CIP modules biomass sensors, perfusion systems and many more.

Control
Applikon offers a choice of ez-Control and i-Control process control systems. Both systems offer automated Sterilization procedures. The i-Control adds automated Clean-In-Place procedures to the Bio Bench systems. The Bio Bench bioreactors can also be used with control systems that are already in place at the customers site. The BioXpert software is used for data collection, data visualization and advanced supervisory control actions.

Specifications

Bioreactor type  7 liter Bio Bench  15 liter Bio Bench  20 liter Bio Bench  30 liter Bio Bench
 Inner Diameter (mm)  162 mm  211 mm  211 mm  265 mm
 Inner Height (mm)  325 mm  442 mm  607 mm  546 mm
 Liquid Height (mm)  248 mm  300 mm  447 mm  413 mm
 Ports Head Space section  5 x 16 mm  5 x 27 mm  5 x 27 mm  2 x 16 mm

5 x 27 mm

1 x 1.5"TC

 Ports Bottom section  3 x DN 25  5 x DN25  5 x DN25  5 x DN25
 Ports Head Plate 1 x M30x1,

5 x 10 mm,

4 x 16 mm,

4 x 27 mm

1 x 69 mm,

3 x 1.5"TC,

3 x 16 mm,

4 x 27 mm

1 x 69 mm,

3 x 1.5"TC,

3 x 16 mm,

4 x 27 mm

1 x 69 mm,

3 x 1.5"TC,

3 x 16 mm,

4 x 27 mm

 Bottom Drain  0.5"TC  0.5"TC  0.5"TC  0.5"TC
 Floor Space (WxD)  530 x 700 mm  530 x 735 mm  530 x 735 mm  443 x 406 mm
 Height  900 mm  1300 mm  1470 mm  802 mm
 Total Volume  7 liter  15 liter  20 liter  30 liter
 Working Volume  5 liter  10 liter  15 liter  22.5 liter
 Min. Working Volume  2 liter  4 liter  4 liter  7 liter
 H/D Total  2.2  2.1  3.0  2.0
 H-D Work Vol.  15  1.4  2.1  1.6
 Design Pressure Reactor  3.1 barg  3.1 barg  3.1 barg  3.1 barg
 Design Pressure Jacket  6.2 barg  6.2 barg  6.2 barg  6.2 barg
 Max. Temperature Reactor  150 oC  150 oC  150 oC  150 oC