General
AppliFlex is the single use bioreactor range designed by Applikon. Manufactured according to the highest quality standards and backed by 35 years of bioreactor and sensor experience, an accurate measurement and control of important parameters is guaranteed. The combination of the bioreactor with sensors and control system offers great opportunities for cGMP applications. The Appliflex bioreactor range consists of a 10-liter, 20-liter and 50-liter bioreactor bag. The bag and sensors (pH, DO, T) are designed for single-use. Optionally a re-usable sensor set can be used. The AppliFlex Rocker is designed in compliance with CE guidelines. It can be applied for a range of reactor volumes. The control system (pH, DO, T, rpm) is formed by the standard Applikon ez-Control.

• Real time measurement of pH, DO, T, agitation
• Accurate control of pH, DO, T, agitation
• Data logging & SCADA (21CFR part 11) available
• Validatable system (total)
• Standard available retrofit options:
• combination with 3rd party systems
• Qualified support and service

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Specifications

• Real time measurement of pH, DO, T, rocking speed
• Classic sensor measurement of pH, DO
• Fluorophore sensor measurement of pH, DO
• Accurate control of pH, DO, T, rocking speed
• Data logging & SCADA (21CFR part 11) available
• Validatable system
• Maximum working volume 5, 10, 25L
• Minimum working volume 2, 5, 10L
• Total volume 10, 20, 50L
• Oxygen transfer can be increased by increasing the rocking rate and the angle of the bioreactor bag
• Lower shear stress levels than in stirred cell culture bioreactors

Features
The AppliFlex system is ideal for cell culture. Especiall the growth of animal cells like CHO cells, Hybridoma cellines and insect cells like Sf-9, Sf-21 cells. The AppliFlex system also works excellent for the seeding of pre-seeding for larger cell cultivation systems.

The AppliFlex system is ideal for cell culture. Especiall the growth of animal cells like:

• CHO cells,
• Hybridoma cellines and
• insect cells like Sf-9, Sf-21 cells.

The AppliFlex system also works excellent for the seeding of pre-seeding for larger cell cultivation systems. Since the materials for the single-use bags is the same as what is used for the larger stirred tank SUB's, the Appliflex is an ideal seed system for larger scale SUB production systems. Validation is simplified since the contact materials in these systems is the same.

  AppliFlex Brochure