The PALL/ATMI PadReactor system is perfectly suited to laboratory environments, process development centers, clinical material supply and flexible GMP manufacturing. The square bioreactor vessel, which offers comparable functionality to classical stirred tank bioreactors, is a single-use bag integrating an internal paddle mixing and sparger system. The sparger is integrated in the paddle mixer to enhance oxygen transfer rates. The innovative bag design improves mixing at low shear forces and allows a non-invasive stirrer connection to the system. The paddle is enclosed in a medical grade ULDPE sleeve, made from the same contact material as the bag itself, and is coupled on top of the vessel with the mechanical mixing head. The PadReactor is available in total volumes of 25L, 50L, 250L, 600L, 1200L and has been used successfully in cultivation of anchorage dependent and suspension cells.
The bioreactor vessel, which offers comparable functionality to classical stirred tank bioreactors, is a single-use bag integrating an internal paddle mixing and sparger system. This innovative bag design allows a non-invasive connection to the system. The paddle is enclosed in a medical grade ULDPE sleeve, made from the same contact material as the bag itself, and is coupled on top of the vessel with the mechanical mixing head.
The Integrity PadReactor utilizes disposable mixing bags made from Integrity TK8 bioprocess film. The product-contacting layer of TK8 film is blow-extruded in-house by Pall under cleanroom conditions using medical-grade ultra low-density polyethylene resin. It is then laminated to create a gas barrier film of exceptional cleanliness, strength, and clarity that is animal derived component free (ADCF) and complies fully with USP Class VI requirements.
The Integrity PadReactor single-use bioreactor consists of the following:
Drive Unit: The flexible drive unit allows the system to cultivate cells in disposable bags. One drive unit can allow the user to mix in multiple disposable mixing bags of various sizes. Each system comes with the appropriate mixing stick for your container.
Mobile Retaining Tank: The purpose of the retaining tank is to support the mixing bag and provide mobility before and after operation. Various tank sizes and options are available.
Bioreactor Vessel: The reactor vessel uses an innovative bag design that allows a non-invasive connection to the mixer. Mixing is achieved when the integrated paddle/sparger inside the bag rotates within the bag.
PAD reactor Volumes
|Total Volume (L)||16||25||50||125||250||600||1200|
|Minimum Working Volume (L)||3.2||8||10||25||25||120||240|
PAD reactor Weight and Dimensions
|Dimension||Bag Holder 25L||Bag Holder 50L||Bag Holder 250L||Bag Holder 600L||Bag Holder 1200L|
|Width||439 mm||439 mm||689 mm||853 mm||1120 mm|
|Depth||559 mm||559 mm||878 mm||1075 mm||1265 mm|
|Height without Drive Unit||680 mm||700 mm||1425 mm||1435 mm||1600 mm|
|Total PadReactor Height||1132 mm||1132 mm||1875 mm||1900 mm||2100 mm|
|With Drive Unit Positioned:|
|Jacket Liguid Volume||13 L||17 L||44 L||105 L||124 L|
|Total Weight (Empty Bag)||74 kg||75 kg||200 kg||225 kg||300 kg|