pilot plant bioreactor systems 1Steam In Place Pilot Systems
applikonThe Applikon Pilot system bioreactor range is divided in a microbial range and in a cell culture range of volumes. The microbial Sterilizable-In-Place bioreactor systems come in a total volume of 20 liter, 40 liter, 70 liter and 140 liter. The cell culture Sterilizable-In-Place bioreactor systems come in a total volume of 30 liter, 60 liter and 130 liter. The main difference between these two lines is the aspect ratio of the bioreactors. The microbial system have an aspect ratio of 3.0 at total volume while the cell culture systems have an aspect ratio of 1.5 at total volume. Applications are pilot plant and small scale production for both mammalian cells and micro-organisms. The pilot range is the first step in the scale-up to production level and these systems have the same functionality as the full production scale. This minimizes risks in process transfer to the final production volume.  The small footprint guarantees that the minimal amount of floor space is occupied by the system. All systems are fully documented for cGMP usage and are supplied with an extensive documentation package to support validation.

Modularity
A wide range of standard and extensively tested modules is available to customize the systems to the specific demands of the customer. The modularity extends to the control systems that can be supplied with the systems. A wide range of add-on packs are available. These standard packs include pressure control, weight control, double gas inlet lines, CIP modules, biomass sensors, perfusion systems and many more.

pilot plant bioreactor systems 2

Control
Applikon offers a choice of ez-Control and i-Control process control systems. The i-Control can be supplied with an Allen Bradley or with a Siemens PLC. Both systems offer automated Sterilization procedures. The i-Control software is just as customizable as the pilot system hardware. The basic software is capable of completely automatic control of the most complex bioreactor system. The i-Control is customized by disabling the un-used features for the specific application. This means that when process demands changes, the controller can easily be adapted to these new demands but enabling the extra functionality. No additional programming is needed so no extra paperwork is required for validation of the control system. The Pilot bioreactors can also be used with control systems that are already in place at the customers site. The BioXpert software is used for data collection, data visualization  and advanced supervisory control actions.

Specifications

Application

Microbial culture

 Cell culture

 Bioreactor type

 20 liter

 40 liter

 70 liter

 140 liter

 30 liter

 60 liter

 130 liter

 Inner Diameter (mm)

 211 mm

 265 mm

 395 mm

 395 mm

 320 mm

 395 mm

 491 mm

 Inner Height (mm)

 631 mm

 795 mm

 957 mm

 1158 mm

 448 mm

 566 mm

 764 mm

 Liquid Height (mm)

 440 mm

 546 mm

 655 mm

 850 mm

 300 mm

 388 mm

 604 mm

 Ports Head Space section

 5 x 27 mm

 5 x 27 mm

 5 x 27 mm

 6 x 27 mm

 5 x 27 mm

 5 x 27 mm

 6 x 27 mm

 Ports Bottom section

 5 x DN 25

 5 x DN 25

 5 x DN 25

 7 x DN 25

 5 x DN 25

 5 x DN 25

 7 x DN 25

 Ports Head Plate

 1 x 69 mm

 3 x 16 mm

 4 x 27 mm

 3 x 1.5" TC

 1 x 69 mm

 3 x 16 mm

 4 x 27 mm

 3 x 1.5" TC

 1 x 69 mm

 3 x 16 mm

 4 x 27 mm

3 x 1.5" TC

 1 x 69 mm

 2 x 16 mm

 5 x 27 mm

 3 x 1.5" TC

 2 x 2" TC

 1 x 3" TC

 1 x 69 mm

 3 x 16 mm

 4 x 27 mm

 3 x 1.5" TC

 1 x 69 mm

 3 x 16 mm

 4 x 27 mm

 3 x 1.5" TC

 1 x 69 mm

 2 x 16 mm

 5 x 27 mm

 4 x 1.5" TC

 2 x 2" TC

 Bottom Drain

 0.5"TC

 1"TC

 1.5"TC

 1.5"TC

 1"TC

 1.5"TC

 1.5"TC

 Floor Space (WxD)

 1250 x 800 mm

 1250 x 800 mm

 1250 x 800 mm

 1500 x 1000 mm

 1250 x 800 mm

 1250 x 800 mm

 1500 x 1000 mm

 Height

 2100 mm

 2100 mm

 2100 mm

 2750 mm

 2100 mm

 2100 mm

 2100 mm

 Total Volume

 20 liter

 40 liter

 70 liter

 140 liter

 30 liter

 60 liter

 130 liter

 Working Volume

 15 liter

 30 liter

 50 liter

 100 liter

 20 liter

 40 liter

 100 liter

 Min. Working Volume

 5 liter

 7.5 liter

 10 liter

 20 liter

 7.5 liter

 10 liter

 28 liter

 H/D Total

 3.0

 3.0

 3.0

 3.0

 1.5

 1.5

 1.5

 H-D Work Vol.

 2.2

 2.2

 2.2

 2.2

 1.0

 1.0

 1.0

 Design Pressure Reactor

 3.1 barg and full vacuum

 3.1 barg and full vacuum

 3.1 barg and full vacuum

 3.1 barg and full vacuum

 3.1 barg and full vacuum

 3.1 barg and full vacuum

 3.1 barg and full vacuum

 Design Pressure Jacket

 6.2 barg and full vacuum

 6.2 barg and full vacuum

 6.2 barg and full vacuum

 6.2 barg and full vacuum

 6.2 barg and full vacuum

 6.2 barg and full vacuum

 6.2 barg and full vacuum

 Max. Temperature Reactor

 150 oC

 150 oC

 150 oC

 150 oC

 150 oC

 150 oC

 150 oC

Our Location

Contact

RTD Technology Ltd T/A Asistec
Unit 23, Southern Cross Business Park
Boghall Road, Bray
Co. Wicklow, A98 XC52
Tel:  +353  (0)1 286 8796
Tel:  +353  (0)1 286 8797
Fax: +353  (0)1 286 5380


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